Genetic basis of prostate cancer: Association studies

Authors

  • Goran Brajušković Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO box 43, Belgrade 11000, Serbia
  • Zorana Nikolić Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO box 43, Belgrade 11000, Serbia
  • Ana Branković The Academy of Criminalistic and Police Studies, Belgrade, Cara Dušana 196, Beograd 11080, Serbia
  • Nevena Kotarac Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO box 43, Belgrade 11000, Serbia
  • Dušanka Savić-Pavićević Center for Human Molecular Genetics, Faculty of Biology, University of Belgrade, Studentski trg 16, PO box 43, Belgrade 11000, Serbia

Keywords:

association studies, genetic variants, prostate cancer

Abstract

Prostate cancer (PCa) is the most common malignancy in men. This paper reviews the results of previous work of the study group PROSTATSERBIA. In the candidate gene association study at the beginning of our research, we tested the association between several single nucleotide polymorphisms (SNPs) in the NOS3 gene and PCa risk and/or progression. In a population-based case-control study, we explored the possible association between PCa risk and seven SNPs identified by genome-wide association analyses (GWASs) in two chromosomal regions (8q24 and 17q12). For the first time in a European population, microRNA genetic variants and genetic variants in RNA-induced silencing complex (RISC) genes have been analyzed for their potential association with PCa.

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Published

2017-07-20

How to Cite

Brajušković, G., Zorana Nikolić, Branković, A., Kotarac, N., & Savić-Pavićević, D. (2017). Genetic basis of prostate cancer: Association studies. Biologia Serbica, 39(1). Retrieved from https://journal.pmf.uns.ac.rs/index.php/biologiaserbica/article/view/133

Issue

Vol. 39 No. 1 (2017): Biologia Serbica

Section

Mini review