The protein folding problem

Authors

  • Brankica G. Janković Department of Biochemistry, Faculty of Chemistry – University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Republic of Serbia
  • Natalija Đ. Polović Department of Biochemistry, Faculty of Chemistry – University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Republic of Serbia

Keywords:

folding code, funnel energy landscapes, folding kinetics, protein aggregation, protein misfolding, structure prediction

Abstract

The protein folding problem is the most important unsolved problem in structural biochemistry. The problem consists of three related puzzles: i) what is the physical folding code? ii) what is the folding mechanism? and iii) can we predict the 3D structure from the amino acid sequences of proteins? Bearing in mind the importance of protein folding, misfolding, aggregation and assembly in many different disciplines, from biophysics to biomedicine, finding solutions that would be generally applicable is of the utmost importance in biosciences.

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Published

2017-07-20

How to Cite

Janković , B. G., & Polović, N. Đ. (2017). The protein folding problem. Biologia Serbica, 39(1). Retrieved from https://journal.pmf.uns.ac.rs/index.php/biologiaserbica/article/view/141

Issue

Vol. 39 No. 1 (2017): Biologia Serbica

Section

Mini review