Phytochemical, pharmacological and clinical studies of an extract prepared from silver fir branches (Abies alba)

Abstract

Abies alba (silver fir) is a tree native to the mountains of Europe, that has rarely been used in traditional phytotherapy. Its bark, wood and particulary branches are rich in antioxidative polyphenols among which lignans (taxiresinol, 7-(2-methyl-3,4-dihydroxytetrahydropyran-5-yloxy)-taxiresinol, secoisolariciresinol, laricinresinol, hydroxymatairesinol, isolariciresinol, matairesinol and pinoresinol) are the most characteristic. In our group, we optimised an extraction procedure under the name Belinal. In several pharmacological, toxicological and clinical studies the extract has been shown to prevent atherosclerosis in guinea pigs and to have cardioprotective effect in isolated rat hearts. It was found to reduce the post-prandial glycaemic response in healthy volunteers. Its topical use improved skin appearance and function. We found no influence on liver and kidney function. The production of this extract and its use has been patented and in collaboration with industrial partners was put on the market as a food supplement.